临床药学研究所
研究成果

发表论文

[1] Fang X, Huang W, Sun Q, Zhao Y, Sun R, Liu F, Huang D, Zhang Y, Gao F, Wang B. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life Sci. 2023; 332:122108.

[2] Yu H, Liu S, Wu Z, Gao F. GNAI2 Is a Risk Factor for Gastric Cancer: Study of Tumor Microenvironment (TME) and Establishment of Immune Risk Score (IRS). Oxidative medicine and cellular longevity, 2022; 1254367.

[3] Zhang Y, Zheng J, Jiang Y, Huang X, Fang L. Neglected, drug-induced platinum accumulation causes immune toxicity. Frontiers in Pharmacology, 2020; 11:1166.

[4] Zhang Y, Huang X, Feng S, Chen C, Guo D, Fang L. Platinum accumulation and cancer-related fatigue,correlation with IL-8, TNF-α and Hemocytes. Frontiers in Pharmacology, 2021; 12:658792.

[5] Gao F, Chen D, Ma X, Sudweeks S, Yorgason JT, Gao M, Turner D, Eaton JB, McIntosh JM, Lukas RJ, Whiteaker P, Chang Y, Steffensen SC, Wu J. Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol. Neuropharmacology. 2019;149:45-54.

[6] Chen D#, Gao F#, Ma X, Eaton JB, Huang Y, Gao M, Chang Y, Ma Z, Der-Ghazarian T, Neisewander J, Whiteaker P, Wu J, Su Q. Cocaine Directly Inhibits alpha6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons. Frontiers in pharmacology. 2019;10:72.

[7] Zhuo Y, Cai X, Hou Z, Zhu Z, Cai D. Postoperative Recurrent Gout Flares: A Cross-sectional Study From China. J Clin Rheumatol 2019 Sep 02.

[8] De Cai, Xiao-Pu Chen, Dun-Can Wei, et al. Combination therapy with beraprost sodium and aspirin for acute ischemic stroke: a single-center retrospective study. Journal of International Medical Research, 2019, 47(7): 3014-3024.

[9] De Cai, Duncan Wei, Siqia Chen, et al. MIR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4. Life Sciences, 2019, 231(30):1-11.

[10] Zhang Q, Chen W, Chen S, et al. Identification of key genes and upstream regulators in ischemic stroke. Brain and Behavior, 2019, 9(7): e01319.

[11] Zhang Q, Zhuo Y, Chen P, et al. Pleural lavage of amphotericin B for treatment of empyema caused by Candida albicans iffections: A case report. pakistan journal of pharmaceutical sciences, 2019, 32(6): 2751-2753.

[12] Chen SMao DWei D, He W. Human urinary kallindinogenase therapy for acute ischemic stroke according to Chinese ischemic stroke subclassification: Clinical efficacy and risk factors. Brain and Behavior, 2019.

[13] Yan Z, Shen D, Liao J, Zhang Y, Chen Y, Shi G*, Gao F*. Hypoxia Suppresses TGF-B1-Induced Cardiac Myocyte Myofibroblast Transformation by Inhibiting Smad2/3 and Rhoa Signaling Pathways. Cell Physiol Biochem. 2018;45(1):250-257.

[14] Chen D#, Gao FF#, Ma XK, Shi GG, Huang YB, Su QX, Sudweeks S, Gao M, Dharshaun T, Eaton JB, Chang YC, McIntosh JM, Lukas RJ, Whiteaker P, Steffensen SC, Wu J. Pharmacological and functional comparisons of alpha6/alpha3beta2beta3-nAChRs and alpha4beta2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line. Acta Pharmacol. Sin. 2018; 39: 1571-1581.

[15] Luo H, Wood K, Shi FD, Gao F*, Chang Y*. Suramin is a novel competitive antagonist selective to alpha1beta2gamma2 GABAA over rho1 GABAC receptors. Neuropharmacology. 2018; 141: 148-157.

[16] Kang Y, Wu Z, Cai D, Lu B. eva luation of reference genes for gene expression studies in mouse and N2a cell ischemic stroke models using quantitative real-time PCR. BMC Neurosci. 2018 Feb 1;19(1):3.

[17] Zhuo Y, Cai X, Hou Z, Zhu Z, Cai D. Postoperative Recurrent Gout Flares: A Cross-sectional Study From China. J Clin Rheumatol. 2020, 26(5):197-203.

[18] Kang Y, Wu Z, Cai, Lu B. eva luation of reference genes for gene expression studies in mouse and N2a cell ischemic stroke models using quantitative real-time PCR. BMC Neurosci. 2018,19(1):3.

[19] Wei DC. Synthesis of substituted aromatic heterocyclic sulfonyl hydrazone compounds and in vitro anti-hepatoma activity: preliminary results[J]. European Review for Medical and Pharmacological Sciences, 2018, 22(14): 4720-4729.

[20] Kang Y, Wu Z, Cai, Lu B. eva luation of reference genes for gene expression studies in mouse and N2a cell ischemic stroke models using quantitative real-time PCR. BMC Neurosci. 2018,19(1):3.

[21] He W, Wei D, Cai D, S Chen, S Li, W Chen. Altered long non-coding RNA transcriptomic profiles in ischemic stroke. Human Gene Therapy.2017 Dec 28.

[22] Yang S, Liu G, Tang D, Cai D. eva luation Intravenous Drip Cephazolin Prophylaxis of Breast Cancer Surgery Site Infection. J Craniofac Surg. 2017 Sep;28(6): e527-e531.

[23] Yang S, Liu G. Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma. Oncology Letters, 2017, 13(3):1041.

[24] Yang S, Liu G, Tang D. eva luation Intravenous Drip Cephazolin Prophylaxis of Breast Cancer Surgery Site Infection. Journal of Craniofacial Surgery, 2017, 28(6): e527.

[25] Huang Y#, Liu G#, Yang F, et al. Induction of apoptosis and proliferation inhibition of hepatocellular carcinoma by 6-chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA): in vitro and vivo studies. Cancer Cell International, 2017, 17(1):66.

[26] Wu Z, Wu P, Zuo X, Yu N, Qin Y, Xu Q, He S, Cen B, Liao W, Ji A. LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation. Molecular neurobiology 2017, 54(10):7670-7685.

[27] Lu S, Zhang Y, Zhong S, Gao F, Chen Y, Li W, et al. N-n-butyl Haloperidol Iodide Protectes against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway. Frontiers in pharmacology.2016;7:520.

[28] Chen H, Luo S, Zheng X. Separation of matrine and oxymatrine from Sophora flavescens extract through cation exchange resin coupled with macroporous absorption resin. Polish Journal of Chemical Technology, 2016,18(2): 31-39.

[29] Zhuo Y, Zhang Q, Tang D, Cai D. The effectiveness of i.v. cefuroxime Prophylaxis of surgical site infection after elective inguinal hernia repair with mesh: A retrospective observational study. Eur J Clin Pharmacol.2016,72(9):1033-9.

[30] Chen X, Kang Y, Wang L, LiY, LuoY W, Zhu Z, Chen R*. Addition to inhaled corticosteroids of leukotriene receptor antagonists versus the ophylline for symptomatic asthma: a meta-analysis. J Thorac Dis. 2015, 7(4):644-652.

[31] Huang Y#, Gao F#, Wang B, Zheng F, Zhang Y, Chen Y, Huang Z, Yan-Shan Zheng, Zhong SP, Shi GG*. N-n-Butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+ exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes. Drug Des Dev Ther. 2014;2014(8): 1257-1267.

[32] Wu Z, Liu X, Liu L, Deng H, Zhang J, Xu Q, Cen B, Ji A. Regulation of lncRNA expression. Cellular & molecular biology letters,2014,19(4):561-575.

 

获得专利

 

 

[1] 国家发明专利:一种甾体查尔酮及其酯类衍生物及其制备方法和应用,蔡晓锐,赵树林,辛岱珊2022年;

[2] 国家实用新型专利一种握笔式移液枪张浴玲,高分飞,黄玮仪,黄丹梅2022年;

[3] 国家实用新型专利一种药学用药材分类存放装置佘玉奇,林沐丽,陈钟琳2021年;

[4] 国家实用新型专利一种一次性便携式简易毒性药品配置台方翎,陈晨,陈钟琳,黄晓婷,冯珊娜2021年;

[5] 国家实用新型专利一种静配中心专用的药框清洗装置方翎,张浴玲,高分飞2021年;

[6] 国家实用新型专利一种便携式简易手握式输液袋检漏器郭岱年,黄晓婷,方翎2021年;

[7] 国家实用新型专利一种温控培养皿细胞浴槽高分飞, 吴杰, 陈海波,2019年;

[8] 国家发明专利:脑卒中患者远程诊疗及协助康复的系统蔡德,何文贞,魏敦灿2017年;

[9] 国家发明专利:分级诊疗及协助脑卒中患者康复的远程系统何文贞,蔡德,魏敦灿2017年;

[10] 国家实用新型专利:改良的脑片/组织片的孵育盒高分飞2016年。

 

科学技术奖

[1] 2015汕头市科学技术奖三等奖单病种管理模式在基层医疗实践中的应用研究

[2] 2007年广东省科学技术奖二等奖:氟哌啶醇季铵盐衍生物抗心肌缺血的作用及机理

[3] 2004年汕头市科技进步奖一等奖:氟哌啶醇季铵盐衍生物F2抗心肌缺血的作用及机