课题组

 

叶曙教授心血管疾病遗传学课题组

简介:课题组负责人叶曙教授为英国伦敦大学正教授及汕头大学医学院兼职教授,在牛津大学及伦敦大学从事心血管疾病遗传学研究20多年,己发表SCI论文100余篇。其实验室在致病基因的功能性研究领域处于国际领先地位。

叶曙教授简介:

叶曙,中山医科大学医学博士(1991)、伦敦大学学院(University College London)心血管遗传学博士(PhD,1996)、牛津大学博士后(1996-1998)。2008年起任伦敦大学玛丽皇后学院正教授。长期从事心血管病的遗传及细胞和分子生物学研究。发表SCI论文百余篇,总影响因子>670,总引用次数>4500。任Heart期刊和BMC Med Genet期刊副主编。
代表性论文 (*为通信作者):
Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker JC, Tang WH, Johnson JA, Wang QK, Assimes TL, N?thlings U, Farrall M, Watkins H, Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S*. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am CollCardiol61:957-70; 2013.
Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai TN, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q, Ye S*. Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions.Circ Res 112:35-47; 2013.
Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ, Ye S*. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.Am J Hum Genet 92:366-74; 2013.
Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ, Ye S*.Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.Hum Mol Genet21:4021-9; 2012.
Schunkert H, ….,Ye S, …., Samani N. Large-scale association analysis identifies 13 newsusceptibility loci for coronary artery disease. Nat Genet43:333-8; 2011.
Kiechl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC, Xiao Q, Bonora E, Willeit J, Xu Q, Witteman JC, Chasman D, Tracy RP, Ballantyne C, Ridker PM, Benjamin EJ, Ye S*.Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis. CircCardiovasc Genet 4:681-6; 2011.
Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, K?h?nen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtim?ki TJ, Keavney B, Xu Q, Ye S*. Coronary artery disease related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. ArteriosclerThrombVascBiol 30:2678-2683; 2010.
Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung KY, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q, Ye S*. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res105:921-929; 2009(accompanied by an editorial). Ye S*, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis – a population-based, prospective study.J Am CollCardiol52:378-84; 2008(accompanied by an editorial). Hodgkinson CP, Laxton RC, Patel K, Ye S. Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway - implications for diabetic atherosclerosis.ArteriosclerThrombVascBiol28:2275-81; 2008.
Kyriakou T, Pontefract DE, Viturro E, Hodgkinson CP, Laxton RC, Bogari N, Cooper G, Davies M, Giblett J, Day IN, Simpson IA, Albrecht C, Ye S*. Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients.Hum Mol Genet 16:1412-22; 2007.
Pearce E, Tregouet D, Samneg?rd A, Morgan AR, Cox C, Hamsten A, Eriksson P, Ye S*. Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction.Circ Res 97:1070-76;2005 (accompanied by an editorial). Kyriakou T, Hodgkinson CP, Pontefract D, Iyengar S, Howell WM, Wong YK, Eriksson P, Ye S*. Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.ArteriosclerThrombVascBiol 25:418-23; 2005.
Beyzade S, Zhang S, Wong YK, Day IN, Eriksson P, Ye S*.Influences of MMP-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction.J Am CollCardiol41:2130-7; 2003.
Zhang BP, Ye S*, Herrmann SM, Eriksson P, de Maat M, Evans A, Arveiler D, Luc G, Cambien F, Hamsten A, Watkins H, Henney A. A functional polymorphism in the regulatory region of the gelatinase B gene associated with severity of coronary atherosclerosis. Circulation 99:1788-1794; 1999.