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细胞生物学与遗传学教研室
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科研之窗

黄东阳
学术研究
    黄东阳教授常年坚持以“正常细胞和肿瘤细胞中的维甲酸代谢及其作用机制”为研究内容,以第一作者或通讯作者的身份在SCI收入期刊发表论文20余篇,研究项目获得国家自然基金面上项目资助3项,省部级项目资助4项,研究成果于2001年获得中国高校科学技术奖二等奖。近年来在Hypertension、Cardiovescular Research、International Journal of Cancer、Experimental Cell Research、Toxicological Science等国际知名学术期刊发表多篇研究论文,标志着黄东阳教授在该领域的研究达到国际先进水平。

近五年研究课题

近五年发表论文
1. Bin Liang, Xuhong Song, Gefei Liu, Rui Li, Jianping Xie, Lifeng Xiaoa, Mudan Du, Qiaoxia Zhang, Xiaoyuan Xu, Xueqiong Gan and Dongyang Huang. Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis. Experimental Cell Research, 2007,313(13): 2833-2844. (IF3.78)
2. Xu-Hong Song, Bin Liang, Ge-Fei Liu, Rui Li, Jian-Ping Xie, Kun Du, Dong-Yang Huang*. Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. International Journal of Cancer, 2007,120(8): 1618-1626. (IF4.69)
3. Yan-Mei Yang, Dong-Yang Huang*, Ge-Fei Liu, Jiu-Chang Zhong, Kun Du, Yi-Fan Li, Xu-Hong Song. Inhibitory effects of Vitamin A on TCDD-induced cytochrome P-4501A1 enzyme activity and expression. Toxicological Sciences,2005 ,85(1): 727-734 (IF3.6)
4. Zhong JC, Huang DY*, Liu GF, Jin HY,Yang YM, Li YF, , Song XH, Du K. Effect of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats. Cardiovascular Research.,2005, 65(3): 743-750. (IF5.3)
5. JC Zhong, DY Huang*, YM Yang, YF Li, GF Liu, XH Song, and K Du. Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats. Hypertension,2004, 44:907-912 (IF6.3)

 

黄天华
学术研究
    黄天华教授为国务院批准享受政府特殊津贴专家,长期从事分子生殖生物学研究,发现了乙肝病毒经人生殖细胞垂直传递的新途径。现任国际环境诱变剂学会会员、中国环境诱变剂学会副秘书长、中国遗传学会法学伦理社会问题委员会副主任委员,兼任《癌变.畸变.突变》杂志常务副主编、《中华实用医学杂志》常务编委、《国际遗传学杂志》编委。黄天华先后承担联合国人口基金、国家和省自然科学基金、国家部委、省厅级课题共12项,在国内外学术期刊发表论文114篇,译文30篇。研究成果分别于1995年和1998年获卫生部、化学工业部科学技术进步奖三等奖,2006年获“第7届ROYAN国际科学研究奖”第2名,成为第一个获得该奖项的中国内地学者。

近五年来课题:

近五年发表论文(均为通讯作者)
1.An improved experimental model for studying vertical transmission of hepatitis B virus via human spermatozoa, Journal of Virological Methods. Journal of Virological Methods, 2008, 151:116-120
2.Single-chain antibody against human lipocalin-type prostaglandin D synthase: construction, expression, purification, and activity assay. Biochemistry (Mosco),2008,73(6): 702-710.
3.Investigation of Recombinant Mouse Sperm Protein Izumo as a Potential Immunocontraceptive Antigen. American Journal of Reproductive Immunology,2008,59: 225-234.
4.Combined eVects of radiotherapy and endostatin gene therapy in melanoma tumor model. Radiat Environ Biophys,2008,47: 285–291.
5.Relationship between contents of lipocalin-type prostaglandin D synthase on the surface of infertility sperm and in seminal plasma. Biochemistry (Moscow), 2007,72(2): 215-218.
6.Expression of hepatitis B virus genes in early embryoniccells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian Journal of Andrology, 2006,8(3): 273-279.
7.Bone Marrow Stromal Cells Express Neural Phenotypes in vitro and Migrate in Brain After Transplantation in vivo. Biomed Environ Sci, 2006,19(5): 329-335.
8.Human umbilical cord Whartton’s Jelly-derived mesenchymal stem cells differentiaion into nerve-like cells. Chinese Medical Journal, 2005,118(23): 1987-1993.
9.GLP(1-37)诱导人胚胎小肠上皮细胞表达胰岛素. Prog. Biochem. Biophys, 2005,32(6): 576-580.
10.Detection and expression of hepatitis B virus X gene in one and two-cell embryos from golden hamster oocytes in vitro fertilized with human spermatozoa carrying HBV DNA. Mol Reprod Dev, 2004,70(1): 30-36.
11.Effect of prenatal exposure to diethylstilbestrol on gubernacular development in fetal male mice. Asian Journal of Andrology, 2004,6(4): 325-329.
12.Effect of Dynein Inhibitor on Mouse Oocyte in vitro Maturation and Its CyclinB1 mRNA Level. Biomed Environ Sci, 2004,17(3): 121-134.

 

刘戈飞
    刘戈飞副教授长期从事肿瘤细胞生物学研究。在卫生部细胞生物学重点实验室工作、学习了九年时间,打下了比较坚实的理论基础和实验技能基础,具有在分子、亚细胞和细胞水平对生命现象进行研究的能力,能够利用现代生物信息学方法指导实验研究。目前作为负责人主持国家自然科学基金1项,广东省自然科学基金2项,已初步形成肿瘤细胞非编码RNA功能研究的科研特色。

近五年来课题:

近五年发表论文
1. 刘戈飞,黄东阳. 辅酶Ⅱ依赖性视黄醇脱氢/还原酶及其选择性剪接亚型的表达与功能鉴定. 军事医学科学院院刊,2006,30(3): 28-33.
2. 刘戈飞,黄东阳,杜晶,崔泽实,宋今丹.人肝脏辅酶II依赖性视黄醛脱氢/还原酶的表达与细胞内定位. 细胞生物学杂志. 2004,26: 433-438.
3. 刘戈飞,李一凡,宋旭红,杜昆,李蕊,谢建平,黄东阳. 神经母细胞瘤辅酶Ⅱ依赖性视黄醇脱氢/还原酶的功能性表达与生物信息学分析. 医学分子生物学杂志,2006,3(2):90-95.
4. 刘戈飞,宋旭红,梁斌,杜昆,黄东阳.辅酶Ⅱ依赖性视黄醇脱氢/还原酶的表达与多克隆抗体制备. 中国医科大学学报, 2006,35(3): 36-39.
5. 刘戈飞,李立梅. 活性氧诱导线粒体损伤导致晶体上皮细胞凋亡的实验研究. 中国组织化学与细胞化学杂志, 2006,15(3): 292-295.
6. Kun Du, Ge-Fei Liu, Jian-Ping Xie, Xu-Hong Song, Rui Li, Bin Liang, Dong-Yang Huang. A 27.368kDa retinal reductase in New Zealand white rabbit liver cytosol encoded by the peroxisomal retinol dehydrogenase-reductase cDNA: purification and characterization of the enzyme. Biochemistry and Cell Biology, 2007,85(1): 1-9. (IF3.4)
7. Bin Liang, Xuhong Song, Gefei Liu, Rui Li, Jianping Xie, Lifeng Xiaoa, Mudan Du, Qiaoxia Zhang, Xiaoyuan Xu, Xueqiong Gan and Dongyang Huang. Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis. Experimental Cell Research, 2007,313(13): 2833-2844. (IF3.8)
8. Xu-Hong Song, Bin Liang, Ge-Fei Liu, Rui Li, Jian-Ping Xie, Kun Du, Dong-Yang Huang. Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. International Journal of Cancer, 2007,120(8): 1618-1626. (IF4.7)
9. Zhong JC, Huang DY, Liu GF, Jin HY,Yang YM, Li YF, , Song XH, Du K. Effect of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats. Cardiovascular Research.,2005, 65(3): 743-750. (IF5.3)
10. Yan-Mei Yang, Dong-Yang Huang, Ge-Fei Liu, Jiu-Chang Zhong, Kun Du, Yi-Fan Li, Xu-Hong So


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