发表论文（#第一作者，*通讯作者）

李凡教授：

[1] Lin Yan#; Litao Wu; Timothy D. Wiggin; Xiaojuan Su; Wei Yan; Hailiang Li; Lei Li; Zhonghua Lu; Yuantao Li; Zhiqiang Meng; Fang Guo; Fan Li*; Leslie C. Griffith*; Chang Liu* . Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep. elife, 2025, eLife14:RP104862.

[2] Yuxun Lu#, Rong Jiang#, Bohao Cui, Mengjun Wang, Jieqin Fang, Fan Li*, Fanyi Kong*, Ying Zhou*. Quantification and visualization of hydrogen peroxide in an ischemic model and serum samples from stroke patients using a reaction-based fluorescence sensor. Sensors and Actuators B: Chemical. Volume 397, 2023, 134662. doi: 10.1016/j.snb.2023.134662.

[3] Ying-Jun Min#, Eng-Ang Ling and Fan Li*. Immunomodulatory Mechanism and Potential Therapies for Perinatal Hypoxic-Ischemic Brain Damage. Front Pharmacol. 2020 Dec 11;11:580428. doi: 10.3389/fphar.2020.580428. PMID: 33536907; PMCID: PMC7849181.

[4] Yingjun Min#, Lin Yan#, Qian Wang, Fang Wang, Hairong Hua, Yun Yuan,Huiyan Jin, Ming Zhang, Yaling Zhao, Jianzhong Yang, Xiangning Jiang*,Yuan Yang* and Fan Li*. Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage. Front Cell Neurosci. 2020 Aug 10;14:244. doi: 10.3389/fncel.2020.00244. PMID: 32903800; PMCID: PMC7438904.

[5] Yingjun Min#, Hongchun Li#, Kaiyu Xu#, Yilong Huang, Jie Xiao, Weizhou Wang, Longjun Li, Ting Yang, Lixuan Huang, Ling Yang, Hong Jiang, Qian Wang, Min Zhao, HaiRong Hua, Rong Mei and Fan Li*. Minocycline-Suppression of Early Peripheral Inflammation Reduces Hypoxia-Induced Neonatal Brain Injury. Front Neurosci. 2017 Sep 12;11:511. doi: 10.3389/fnins.2017.00511. PMID: 28955196; PMCID: PMC5600962.

[6] Shu Wei#,Hai-Rong Hua#,Qian-Quan Chen,Ying Zhang, Fei Chen, Shu-Qing Li, Fan Li*, Jia-Li Li*. Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging. Zool Res. 2017 Mar 18;38(2):96-102. doi: 10.24272/j.issn.2095-8137.2017.013. PMID: 28409505; PMCID: PMC5396032.

[7] Sophorn Chip#, David Fernández-López, Fan Li*, Joel Faustino, Nikita Derugin, Zinaida S. Vexler*. Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke. Brain Behav Immun. 2017 Feb; 60:270-281. doi: 10.1016/j.bbi.2016.11.005. Epub 2016 Nov 9. PMID: 27836669; PMCID: PMC7909718.

[8] Jie Xiao#, Yilong Huang, Xia Li, Longjun Li, Ting Yang, Lixuan Huang, Ling Yang, Hong Jiang, Hongchun Li, Fan Li*. TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline. Neurosci Bull. 2016 Feb;32(1):99-107. doi: 10.1007/s12264-015-0003-8. Epub 2016 Jan 15. PMID: 26769489; PMCID: PMC5563748.

[9] Li F#, Faustino J, Woo MS, Derugin N, Vexler ZS*. Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. J Neurochem. 2015 Nov;135(3):445-52. doi: 10.1111/jnc.13239. Epub 2015 Sep 3. PMID: 26223273; PMCID: PMC4844456.

[10] Rui Feng#, Shuqing Li, Fan Li*. Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of tree shrews to thrombotic cerebral ischemia. Brain Res. 2011 Apr 12;1384:118-27. doi: 10.1016/j.brainres.2011.02.005. PMID: 21315690.

[11] Fan Li#, Lei Wang, Ji-Wei Li, Min Gong, Liang He, Rui Feng, and Zhen Dai, Shu-Qing Li*. Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor P2X4. BMC Neurosci. 2011 Nov 4;12:111. doi: 10.1186/1471-2202-12-111. PMID: 22053919; PMCID: PMC3239293.

[12] Fan Li#, Lu J, Wu CY, Kaur C, Sivakumar V, Sun J, Li S, Ling EA*. Expression of Kv1.2 in microglia and its putative roles in modulating production of proinflammatory cytokines and reactive oxygen species. J Neurochem. 2008 Sep;106(5):2093-105. doi: 10.1111/j.1471-4159.2008.05559.x. Epub 2008 Jul 9. PMID: 18627436.

[13] Cao Q#, Lu J, Kaur C, Sivakumar V, Fan Li*, Cheah PS, Dheen ST, Ling EA*.  Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia. 2008 Aug 15;56(11):1224-37. doi: 10.1002/glia.20692. PMID: 18449946.

[14] 闵颖俊#，赵俊雄，彭行，曾祥菲，颜琳，华海蓉，毛榕榕，金会艳，李凡*， 小胶质细胞参与新生儿缺氧缺血性脑损伤所致突触异常的研究.中国病理生理学杂志.2021,37(3):385-392.

[15] 颜琳#，张如秋，华海蓉，王茜，曾祥菲，李娟娟，江萍，李凡*， 早期活体判断新生小鼠缺氧缺血性脑损伤程度。解剖学报. 2021,52(5):675-680.

[16] 张丹#，周玉陶，徐玉庭，李志荣，虎鑫，王茜，李虹椿，李凡*， 新生小鼠缺氧缺血性脑损伤模型的建立。中国实验动物学报。2017，05（004）：1005-4847。

[17] 李虹椿#，肖婕，黄益龙，李龙君，江虹，黄丽轩，杨婷，杨泠，李凡*，米诺环素通过抑制炎症因子和谷氨酸转运体表达减轻缺氧所致新生鼠认知损伤，生理学报，2016,301(02):148-156。

[18] 李虹椿#，李霞，马雪涛，肖婕，牛之瑞，冯雷，李凡*，米诺环素对新生鼠缺氧后脑室周围区域谷氨酸清除的影响。中国病理生理杂志。2016,32(2)：290-295。

[19]徐开宇#，杜兴华，王伟州，崔鑫，李凡*， 新生 SD 大鼠血常规各项与发育时间的相关性分析及其与血清铁浓度变化的机制。中国病理生理杂志。2013，29(11):2256-2262。

朱光荣老师：

[1] Zhu G#, Zheng X, Wang Z, Xu X*. Post-Translational Modifications by Lipid Metabolites during the DNA Damage Response and Their Role in Cancer. Biomolecules. 2022 Nov 8;12(11):1655. doi: 10.3390/biom12111655. PMID: 36359005; PMCID: PMC9687621.

[2] Zhu G#, Shi J, Zhang S, Guo Y, Huang L, Zhao H, Jiang Y, Sun J*. Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib. Cell Biosci. 2020 Feb 12;10:16. doi: 10.1186/s13578-020-0377-9. PMID: 32082541; PMCID: PMC7017564.

李英辉老师：

[1] Li YH#, Choi DH, Lee EH, Seo SR, Lee S, Cho EH*. Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells. J Biol Chem. 2016 May 6;291(19):10277-92. doi: 10.1074/jbc.M115.692244. Epub 2016 Feb 24. PMID: 26912655; PMCID: PMC4858976.

[2] Li YH#, Woo SH, Choi DH, Cho EH*. Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells. Biochem Biophys Res Commun. 2015 Aug 7;463(4):853-8. doi: 10.1016/j.bbrc.2015.06.023. Epub 2015 Jun 5. PMID: 26051274.

[3] Kim JH#, Jang JW, Lee YS, Lee JW, Chi XZ, Li YH, Kim MK, Kim DM, Choi BS, Kim J, Kim HM, van Wijnen A, Park I, Bae SC*. RUNX family members are covalently modified and regulated by PIAS1-mediated sumoylation. Oncogenesis. 2014 Apr 28;3(4):e101. doi: 10.1038/oncsis.2014.15. PMID: 24777122; PMCID: PMC4007197.

[4] Lee YS#, Lee JW#, Jang JW#, Chi XZ#, Kim JH, Li YH, Kim MK, Kim DM, Choi BS, Kim EG, Chung JH, Lee OJ, Lee YM, Suh JW, Chuang LS, Ito Y, Bae SC*. Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. Cancer Cell. 2013 Nov 11;24(5):603-16. doi: 10.1016/j.ccr.2013.10.003. PMID: 24229708.

[5] Goh YM#, Cinghu S, Hong ETH, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC*. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. J Biol Chem. 2010 Mar 26;285(13):10122-10129. doi: 10.1074/jbc.M109.071381. Epub 2010 Jan 25. PMID: 20100835; PMCID: PMC2843174.

[6] Lee KS#, Lee YS#, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC*. Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer. Oncogene. 2010 Jun 10;29(23):3349-61. doi: 10.1038/onc.2010.79. Epub 2010 Mar 15. PMID: 20228843.

[7] Kim JH#, Choi JK, Cinghu S, Jang JW, Lee YS, Li YH, Goh YM, Chi XZ, Lee KS, Wee H, Bae SC*. Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3. J Cell Biochem. 2009 Jun 1;107(3):557-65. doi: 10.1002/jcb.22157. PMID: 19350572.

获得专利

李凡教授获得国家发明专利授权1项，“抗菌肽MU1的应用”发明专利（专利号：ZL 2024 1 1600381.7，授权公告号：CN 119139457 B），于2025年1月24日获国家知识产权局授权（排名第一）。