疼痛与相关疾病研究实验室
研究成果

1.Jiang ZJ*, Liu S*, Mu Di*, Zhang FM*, Qian LN, Li QY, Zhang YY, Jing PB, Wang B, Zeng MX, Luo L, Chen Y, Sun Z, Wu J, Lu ZG, Tang ZX, Sun YG, Liu XJ. Endothelial cell regulates vascular pain by modulating neural CGRP system. Nature 2021. (Preparing)

2.Jiang ZJ*, Li QY*, Hao RB, Zhang FM, Huang YK, Gu JH, Li J, Liu XJ. TGF-β superfamily transcription profiles in lumbar DRG of rat with chronic inflammatory pain. Cytokine 2021. (Revised)

3.Jiang ZJ*, Li QY*, Zhang YY, Zeng MX, Hu H, Zhang FM, Bi LB, Gu JH, Liu XJ. Deletion of MyD88 adaptor in nociceptor alleviates low-dose formalin-induced acute pain and persistent pain in mice. 2020 NeuroReport. (Accepted)

4.Huang YK*, Lu YG*, Zhao X*, Zhang JB, Zhang FM, Chen Y, Bi LB, Gu JH, Jiang ZJ, Wu XM, Li QY, Liu Y, Shen JX, Liu XJ. Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel. Br J Pharmacol 2020;177(24): 5642-5657. DOI:10.1111/bph.15284.

5.Mu D, Deng J, Liu KF, Wu ZY, Shi YF, Guo WM, Mao QQ, Liu XJ, Li H, Sun YG. A central neural circuit for itch sensation. Science 2017 Aug 18; 357(6352):695-699. doi: 10.1126/science.aaf4918.

6.Lin SF*, Wang B*, Zhang FM, Fei YH, Gu JH, Li J, Bi LB, Liu XJ. T-type calcium channels, but not Cav3.2, in the peripheral sensory afferents are involved in acute itch in mice. Biochem Biophys Res Commun. 2017; 487(4):801-806. 2017 May 10 (*co-first author)

7.Lin SF*, Yu XL*, Wang B, Zhang YJ, Sun YG, Liu XJ. Co-localization of insulin-like growth factor 1 receptor and T type Cav3.2 channel in dorsal root ganglia in chronic inflammatory pain mouse model. NeuroReport 2016; 27(10): 737-743. (*co-first author)

8.Lin SF*, Yu XL*, Liu XY, Wang B, Li CH, Sun YG, Liu XJ. Expression patterns of T-type Cav3.2 channel and insulin-like growth factor-1 receptor in dorsal root ganglion neurons of mice after sciatic nerve axotomy. NeuroReport 2016; 27(15): 1174-1181. (*co-first author)

9.Liu XJ*, Liu T*, Chen G, Wang B, Yu XL, Yin C, Ji RR. TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and peripheral neuroinflammation. Sci Rep 2016;6: 28188; doi:10.1038/srep28188 (*co-first author)(corresponding author)

10.Liu XJ*, Zhang YL*, Liu T*, Xu ZZ, Berta T, Jiang DH, Ji RR. Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. Cell Res 2014; 24(11):1374-1377.

11.Xu ZZ*, Liu XJ*, Berta T, Park CK, Lü N, Serhan CN, Ji RR. Neuroprotectin D1 protects neuropathic pain after nerve trauma. Ann Neurol 2013;74(3):490-495. (*co-first author)

12.Liu XJ, Zhang FX, Liu H, Li KC, Lu YJ, Wu QF, Li JY, Wang B, Wang Q, Lin LB, Zhong YQ, Xiao HS, Bao L, Zhang X. Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain 2012; 135(Pt 2):391-403. 

13.Liu X, Wang W, Hu H, Tang N, Zhang C, Liang W, and Wang MW. Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-β1 in cultured rat hepatic stellate cells. Pharmaceutical Research 2006; 23(1): 82-89. 

14.Liu XJ, Hu H and Yin JQ. Therapeutic strategies against TGF-β signaling pathway in Hepatic Fibrosis. Liver International 2006, 26(1): 8-22.

15.Liu XJ, Ruan CM, Gong XF, Li XJ, Wang HL, Wang MW, Yin JQ. Antagonists of transforming growth factor-β signaling inhibits fibrosis-related genes. Biotechnology Letters 2005, 27(20):1609-1615.  

16.Zhang Y, Qin W, Qian Z, Liu XJ, Wang H, Gong S, Sun YG, Snutch TP, Jiang X, Tao J. Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels. Sci Signal 2014;7(346):ra94. doi: 10.1126/scisignal.2005283.

17.Park CK, Xu ZZ, Berta T, Han Q, Chen G, Liu XJ, Ji RR. Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron 2014; 82(1):47-54.

18.Zhang FX, Liu XJ, Gong LQ, Yao JR, Li KC, Li ZY, Lin LB, Lu YJ, Xiao HS, Bao L, Zhang XH, Zhang X. Inhibition of inflammatory pain by activating B-type natriuretic Peptide signal pathway in nociceptive sensory neurons. J Neurosci. 2010; 30(32):10927-10938.

19.Liu H, Wu QF, Li JY, Liu XJ, Li KC, Zhong YQ, Wu D, Wang Q, Lu YJ, Bao L, Zhang X. Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. J Mol Cell Biol 2015;7(5):466-475.

20.Zhang C, Tang N, Liu X, Liang W, Xu W, and Torchilin VP. siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene. J Control Releas 2006; 112(2):229-239.