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研究成果

近五年发表论文

 

1. (郑振渊/许丽艳)Zheng ZY# , Yang PL#, Luo W, Yu SX, Xu HY, Huang Y, Li RY, Chen Y, Xu XE, Liao LD, Wang SH, Huang HC, Li EM*, Xu LY*. STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2021 Feb 21;13(4):901.

2. (许丽艳)Liu W#, Xie L#, He YH#, Wu ZY#, Liu LX#, Bai XF, Deng DX, Xu XE, Liao LD, Lin W, Heng JH, Xu X, Peng L, Huang QF, Li CY, Zhang ZD, Wang W, Zhang GR, Gao X, Wang SH, Li CQ, Xu LY*, Liu W*, Li EM*. Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting. Nat Commun. 2021 Aug 16;12(1):4961.

3. (许丽艳)Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY*, Lin DC*, Li EM*. Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment. Nat Commun. 2021 Dec 17;12(1):7335.

4. (程银伟/许丽艳)Cheng YW#, Zeng FM#, Li DJ, Wang SH, He JZ, Guo ZC, Nie PJ, Wu ZY, Shi WQ, Wen B, Xu XE, Liao LD, Li ZM, Wu JY, Zhan J, Zhang HQ, Chang ZJ, Zhang K*, Xu LY*, Li EM*. P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer. Cancer Commun (Lond). 2021 Dec;41(12):1398-1416.

5. (许丽艳)Guo Z#, Pan F#, Peng L, Tian S, Jiao J, Liao L, Lu C, Zhai G, Wu Z, Dong H, Xu X, Wu J, Chen P, Bai X, Lin D, Xu L*, Li E*, Zhang K*. Systematic Proteome and Lysine Succinylome Analysis Reveals the Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Cancer. Mol Cell Proteomics. 2021 Feb 6;20:100053.

6. (许丽艳)Dong H#, Zhang J#, Zhang H, Han Y, Lu C, Chen C, Tan X, Wang S, Bai X, Zhai G, Tian S, Zhang T, Cheng Z, Li E, Xu L*, Zhang K*. YiaC and CobB regulate lysine lactylation in Escherichia coli. Nat Commun. 2022 Nov 4;13(1):6628. doi: 10.1038/s41467-022-34399-y.

7. (程银伟/许丽艳)Zeng FM, Cheng YW, He JZ, Xu XE, Liao LD, Xu LY*, Li EM*. Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin-bundling activity and tumor metastasis in esophageal squamous cell carcinoma.Cancer Commun (Lond).2022 Jul;42(7):668-672.

8. (郑振渊/许丽艳)Zheng ZY, Xu LY*. A response to the commentary by Jianquan Yang, Wen Guo, Rong Huang, Chunyang Zhou, and Man Lu.Cancer Lett. 2022 May 1;533:215596.

9. (郑振渊/许丽艳)Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM(李恩民)*, Xu LY*. Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma.Cell Death Dis. 2022 May 25;13(5):496.

10. (程银伟/许丽艳)Li X#, Li L#, Wu X, Wen B, Lin W, Cao Y, Xie L, Zhang H, Dong G, Li E, Xu L*, Cheng Y*. Anti-tumour effects of a macrolide analog F806 in oesophageal squamous cell carcinoma cells by targeting and promoting GLUT1 autolysosomal degradation. FEBS J. 2022 Nov;289(21):6782-6798

11. (许丽艳)Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM*, Xu LY*. Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells through Activating Ezrin. Mol Cell Proteomics. 2023 Aug; 22(8): 100593.

12. (许丽艳)Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E*, Xu L*. Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2023 Nov 15;117(4):966-978.

13. (许丽艳)Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM*, Xu LY*. Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer. Mol Cell Proteomics. 2023 Apr 17;22(6):100551.

14. (宋旭红)Xuhong Song#, Lulu Zhou, Wenrui Yang, Xinyan Li, Jiazi Ma, Kun Qi, Rui Liang, Meijing Li, Lingzhu Xie, Tin Su, Dongyang Huang*, Bin Liang*. PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis. Mol Cell Biochem.. 2023. doi: 10.1007/s11010-023-04752-w. Online ahead of print.

15. (郑振渊/许丽艳)Zheng ZY, Lin W, Su JW, Huang QF, Zhang C, Pan WX, Li EM, Zhang HF, Xu LY..NIR-715 photodynamic therapy induces immunogenic cancer cell death by enhancing the endoplasmic reticulum stress response. Cell Death Dis. 2024 Dec 18;15(12):890.

 

16. (龙琳/许丽艳)Li C , Pan D, Lin W, Deng D, Zhou Y, Zhao H, Pan F, Xu L*, Li E*, Long L*. RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells. Genes Dis. 2023 Jun 24;11(3):100990. doi: 10.1016/j.gendis.2023.04.024. PMID: 38274384; PMCID: PMC10808919.

17. (程银伟/许丽艳)Li DJ #, Cheng YW #, Pan JM #, Guo ZC, Wang SH, Huang QF, Nie PJ, Shi WQ, Xu XE, Wen B, Zhong JL, Zhang ZD, Wu ZY, Zhao H, Liao LD, Wu JY, Zhang K*, Dong G*, Li EM*, Xu LY*. KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. J Pathol. 2024 May;263(1):74-88.

18. (龙琳/许丽艳)Pan D#, Long L#, Li C, Zhou Y, Liu Q, Zhao Z, Zhao H, Lin W, Zheng Z, Peng L, Li E*, Xu L*. Splicing factor hnRNPA1 regulates alternative splicing of LOXL2 to enhance production of LOXL2Δ13. J Biol Chem. 2024 May 27:107414.

19. (许丽艳)Cao YF, Wang H, Sun Y, Tong BB, Shi WQ, Peng L, Zhang YM, Wu YQ, Fu T, Zou HY, Zhang K, Xu LY, Li EM.Nat Commun. 2025 Feb 2;16(1):1271.

20. (张淑霞)Shuxia Zhang; Xinyi Liao; Suwen Chen; Wanying Qian; Man Li; Yingru Xu; Meisongzhu Yan; Xincheng L; Shuang Mo; Miaoling Tang; Xingui Wu; Yameng Hu; Ziwen Li; Ruyuan Yu; Ainiwaerjiang Abudourousul; Libing Song; Jun Li ; Large Oncosome-Loaded VAPA Promotes Bone-Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre-Metastatic Niche, Advanced science, 2022, 9(31): e2201974

21. (张淑霞)Suwen Chen; Miaoling Tang; Xuexin Yu; Wanying Qian; Yingru Xu; Jun Li; Geyan Wu; Shuxia Zhang; A microprotein encoded by LINC00263 promotes breast cancer osteolytic bone metastasis by inducing osteoclastogenesis and inhibiting osteoclast ferroptosis, Oncogene, 2025.

22. (张淑霞)Jinrong Zhu; Lei Wang; Xiaoya Nie; Shengming Ou; Jianfei Shen; Shuxia Zhang; Geyan Wu; RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma, Oncogene, 2025;44(21):1620-1633.

23. (张淑霞)Yingru Xu; Shuxia Zhang; Xinyi Liao; Man Li; Suwen Chen; Xincheng Li; Xingui Wu; Meisongzhu Yang; Miaoling Tang; Yameng Hu; Ziwen Li; Ruyuan Yu; Mudan Huang; Libing Song; Jun Li ; Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling, Molecular Cancer, 2021, 20(1): 98.

24. (张淑霞)Miaoling Tang, Shuxia Zhang, Meisongzhu Yang, Rongni Feng, Jinbin Lin, Xiaohong Chen, Yingru Xu, Ruyuan Yu, Xinyi Liao, Ziwen Li, Xincheng Li, Man Li, Qiliang Zhang, Suwen Chen, Wanying Qian, Yuanji Liu, Libing Song, Jun Li; Infiltrative vessel co-optive growth pattern induced by IQGAP3 overexpression promotes microvascular invasion in hepatocellular carcinoma. CLINICAL CANCER RESEARCH, 2024 Mar 12.

25. (张淑霞)Ruyuan Yu; Yameng Hu; Shuxia Zhang; Xincheng Li; Miaoling Tang; Meisongzhu Yang; Xingui Wu; Ziwen Li; Xinyi Liao; Yingru Xu; Man Li; Suwen Chen; Wanying Qian; Li-Yun Gong; Libing Song; Jun Li ; LncRNA CTBP1- DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms, Nucleic Acids Res, 2022, 50(14): 8060-8079

 

 

获得的专利

序号

专利名称

发明人

授权时间

专利号

1

人食管癌细胞ezrin基因启动子

许丽艳,高书颖,李恩民

2008.10.22

ZL200610036995.2

2

人食管癌细胞ezrin基因上游转录调控元件

许丽艳,高书颖,李恩民

2009.01.28

ZL200610123684.X

3

人食管癌细胞fascin基因启动子区调控元件

许丽艳,郭张燕,高书颖,杨章民,谢剑君,李恩民

2009.03.04

ZL200710026290.7

4

抑制人ezrin基因表达的siRNA在食管癌细胞移动侵袭研究中的应用

许丽艳,谢剑君,李恩民

2010.07.28

ZL200610037493.1

5

抑制人ezrin基因表达的siRNA在食管癌细胞增殖研究中的应用

许丽艳,谢剑君,李恩民

2011.01.07

ZL200610037492.7

6

抑制人ezrin基因表达的siRNA及其表达载体

许丽艳,谢剑君,李恩民

2011.06.08

ZL200610037491.2

7

Kindlin-2、Myosin-9和Annexin II三蛋白联合预测食管癌患者预后试剂盒

许丽艳,曹卉慧,许秀娥,吴健谊,李恩民

2016.06.08

ZL201410693622.7

8

CD105、esVEGF和MYC三蛋白联合预测食管癌患者预后试剂盒

许丽艳,陈博,许秀娥,吴健谊,李恩民

2018.06.29

ZL201610462797.6


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