研究成果

参与指南制定

林玲教授参与撰写临床指南：

1. 《原发性干燥综合征诊疗规范》（中华内科杂志2020 年4月第59卷第4期）

2. 《原发性干燥综合征超药品说明书用药中国临床实践指南（2023版）》（中华医学杂志2023年11月第103卷第43期）

3. 《利妥昔单抗治疗风湿免疫性疾病中国专家共识（2024版）》（中华风湿病学杂志2024年8月第28卷第8期）

4.《2024中国类风湿关节炎诊疗指南》（中华内科杂志 2024年11月第63卷第11期）

5.《类风湿关节炎中西医结合诊疗专家共识（2025版）》（中华风湿病学杂志2025年3月第29卷第3期）

6. 《非放射学中轴型脊柱关节炎的诊疗指南（2024版）》（中华医学杂志2025年4月第105卷第13期）

已发表的部分SCI收录论文

1. Iguratimod improves bleomycin induced pulmonary inflammation and fibrosis by regulating macrophage polarization through inhibiting the TLR4/NF-κB pathway. Front Immunol. 2025, 16: 1558903.

2. Profiling of IgG N-glycosylation for axial spondyloarthritis and other rheumatic diseases. Arthritis Research & Therapy, 2025, 27(37): 1-13.

3. Development and validation of a new nomogram for self-reported OA based on machine learning: a cross-sectional study. Scientific Reports. 2025 Jan 4;15(1):827.

4. Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003-2016. Sci Rep. 2025, 15(1):1578.

5. Endothelial mesenchymal transition promotes pannus formation in ankylosing spondylitis by activation of TGF-β/SMAD signaling pathway, Clin Exp Rheumatol, 2024, Sep;42(9):1750-1755.

6. Crosstalk Between Cytokines and IgG N-Glycosylation: Bidirectional Effects and Relevance to Clinical Innovation for Inflammatory Diseases. OMICS. 2024, 28(12):608-619. 

7. Association between flavonoid intake and rheumatoid arthritis among US adults. J Nutr Biochem. 2024 Sep; 131:109673.

8. S1PR2 is Important for Cigarette Smoke-induced Pyroptosis in Human Bronchial Epithelial Cells. Arch Med Res.2023,54:277-286. 

9. TGF-β1 promotes human breast cancer angiogenesis and malignant behavior by regulating endothelial-mesenchymal transition. Front Oncol. 2022,12:1051148. 

10. eva luation of Triglyceride Glucose Index and Homeostasis Model of Insulin Resistance in Patients with Polycystic Ovary Syndrome. Int J Womens Health. 2022; 14:1821-1829.

11. Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease. Journal of Diabetes Research; 2022, 9632355. 

12. m6A-related lncRNAs are potential biomarkers for predicting prognoses and immune responses in patients with LUAD. Mol Ther Nucleic Acids,2021,24:780-791.

13. Glycolysis-Based Genes Are Potential Biomarkers in Thyroid Cancer. Front Oncol, 2021,11:534838.

14. SNRNP200 mutations cause autosomal dominant retinitis pigmentosa. Front Med (Lausanne),2021,7:588991.

15. A signature of immune-related gene pairs predicts oncologic outcomes and response to immunotherapy in lung adenocarcinoma. Genomics, 2020: S0888-7543(20)30971-X.

16. Analysis of lung adenocarcinoma subtypes based on immune signatures identifies clinical implications for cancer therapy, Molecular Therapy-Oncolytics, 2020: In press. 

17. A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma, OncoImmunology, 2020, 9(1):1731943.

18. Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma, International Immunopharmacology, 2020, 81: 105932.

19. Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis. Arthritis Res Ther. 2018; 20(1):120. doi: 10.1186/s13075-018-1594-z.

20. Immunohistological analysis of active sacroiliitis in patients with axial spondyloarthritis. Medicine. 2017;96(16)

21. Bone edema on magnetic resonance imaging is highly associated with low bone mineral density in patients with ankylosing spondylitis. PLoS One, 2017, 12(12): e0189569

22. Bone Mineral Density in Patients with Rheumatoid Arthritis and 4-Year Follow-up Results. J Clin Rheumatol, 2016. 22(2): 71-4.

23. Leprosy mimicking connective tissue disease – a challenge for rheumatologists. Int J Clin Exp Med, 2016;9(9): 18040-18046.

24. Preva lence and risk factors of osteoporosis in patients with ankylosing spondylitis: a 5-year follow-up study of 504 cases. Clin Exp Rheumatol, 2015. 33(4): 465-70.

25. Changes in the Preva lence of Rheumatic Diseases in Shantou, China, in the Past Three Decades: A COPCORD Study. PLoS One. 2015;10(9): e0138492. 

26. A long-term, observational cohort study on the safety of low-dose glucocorticoids in ankylosing spondylitis: adverse events and effects on bone mineral density, blood lipid and glucose levels and body mass index.BMJ Open. 2015; 5(6): e006957.

27. Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine. BMC Pharmacol Toxicol. 2014; 15:64. 

28. Apelin-13 decreases lipid storage in hypertrophic adipocytes in vitro through the upregulation of AQP7 expression by the PI3K signaling pathway. Med Sci Monit. 2014; 20:1345-1352. 

29. Decreased activated protein C levels are inversely associated with the urinary albumin excretion rate in patients with type 2 diabetes. Clin Lab, 2014, 60(2):261-266. 

30. miR-150 promotes human breast cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7 receptor. PLoS One, 2013, 8(12): e80707

31. Ten years' experience with needle biopsy in the early diagnosis of sacroiliitis.Arthritis Rheum. 2012;64(5):1399-406. 

32. HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells. PLoS One, 2012, 7(1): e29124.

33. Epidemiologic study of soft tissue rheumatism in Shantou and Taiyuan, China. Chin Med J (Engl), 2010, 123(15):2058-2062.

34. Rheumatic Diseases in China. Arthritis Research & Therapy 2008, 10: R17

35. Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate related toxicity in Chinese Han patients with inflammatory arthritis. Ann Rheum Dis 2008;67:1193－1194.

36. Method for the determination of blood methotrexate by high performance liquid chromatography with online post-column electrochemical oxidation and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 845(1): 164-8.

37. Associated risk factors of knee osteoarthritis: a population survey in Taiyuan, China. Chin Med J. 2006;119(20):1522-7.

38. Risk factors Associated with Rheumatic Complaints: A WHO-ILAR study in Shantou, southeast China. J Rheumatol 2005; 32(5):920-7.

39. Drinking alcohol and gout. The Lancet 2004; 363 (9417): 1251-2.

40. Low Preva lence of Knee and Back Pain in Southeast China; the Shantou COPCORD Study. J Rheumatol 2004; 31:2439-43.

41. Ankylosing spondylitis in Shantou, China: 15 years’ clinical experience. J Rheumatol 2003; 30:1816-21.

42. Primary gout in Shantou: a clinical and epidemiological study. Chin Med J. 2003;116(1):66-9.

43. Futures of spondyloarthritis around the world. Rheum Dis Clin North Am. 1998;24(4):753-9.

44. Rheumatic Diseases in China: ILAR-China Study Comparing the Preva lence of Rheumatic Symptoms in Northern and Southern Rural Populations. J Rheumatol 1994;21(8):1484~1490

主编专著

1. 骨关节炎. 天津科学技术出版社. 1999年. 天津

2. 强直性脊柱炎和其他血清阴性脊柱关节病. 华夏出版社. 1994年. 北京

3. 风湿性疾病的自我调理. 华夏出版社. 1991年. 北京

4. 类风湿关节炎的临床. 华夏出版社. 1989年. 北京

参编的部分专著

1. 全国高校统编教材《内科学》2000年第五版，2004年第六版，2008年第七版

2. 卓大宏2007年出版《康复治疗处方手册》

3. 张文武2007年出版《急诊内科学》

4. 张乃峥1999年出版《临床风湿病学》

5. 陈敏章1999年出版《中华内科学》

译著

1. 肝脏疾病免疫学, 广东科技出版, 1988年 广州.

2. 凯利风湿病学（第八版），北京大学医学出版社，2010年 北京

部分获奖情况

1. 常见风湿病的早期诊断、个体化精准治疗研究，获2024年汕头市第二届汕头医学科技奖一等奖

2. 风湿病流行病学系列研究，获2007年广东省科技进步奖二等奖、2006年汕头市科技进步奖一等奖

3. 骶髂关节的病理学研究，获2005年汕头市科技进步奖一等奖

4. 重症狼疮血液、心脏、神经精神系统损害及早期干预对策研究，获2002年汕头市科技进步二等奖

5. 汕头地区风湿病流行病学研究，获1999年广东省医药卫生科技进步奖三等奖、1998年汕头市科技进步奖三等奖

6. 中国几种主要风湿性疾病的流行病学调查研究，获1999年北京市科学技术进步奖三等奖

7. 骨质疏松的流行病学及其与骨质增生的关系研究，获1997年汕头市科技进步奖三等奖

8. 症状性骨关节炎的流行病学研究，获1996年汕头市科技进步奖三等奖

9. 骶髂关节解剖和强直性脊柱炎的早期放射学诊断，获1992年度汕头市科技进步奖二等奖

10. 类湿性关节炎的临床，获1990年汕头市科技进步奖二等奖

11. 强直性脊柱炎的流行病学和HLA-B27的临床应用研究，获广东省卫生厅科技进步奖三等奖、1988年汕头市科技进步奖一等奖

12. PEG-CIC沉淀比浊法改进的研究，获1986年广东省科技进步奖三等奖