近2年来，生物化学与分子生物学教研室发表SCI论文41篇

1.Cao YF, Wang H, Sun Y, Tong BB, Shi WQ, Peng L, Zhang YM, Wu YQ, Fu T, Zou HY, Zhang K, Xu LY, Li EM. Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression. Nat Commun. 2025 Feb 2;16(1):1271. doi: 10.1038/s41467-025-56645-9. PMID: 39894879; PMCID: PMC11788435.

2.Jin MJ, Li EM, Xu LY. Diagnostic accuracy of breath tests based on volatile organic compounds for cancer: A systematic review and meta-analysis. Clin Biochem. 2025 Mar;136:110898. doi: 10.1016/j.clinbiochem.2025.110898. Epub 2025 Feb 18. PMID: 39978744.

3.Li C, Pan D, Lin W, Deng D, Zhou Y, Zhao H, Pan F, Xu L*, Li E*, Long L*. RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells. Genes Dis. 2023 Jun 24;11(3):100990. doi: 10.1016/j.gendis.2023.04.024. PMID: 38274384; PMCID: PMC10808919.

4.Guo H, Hu WC, Xian H, Shi YX, Liu YY, Ma SB, Pan KQ, Wu SX, Xu LY*, Luo C*, Xie RG*. CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex. Mol Neurobiol. 2024 Aug;61(8):4976-4991 doi: 10.1007/s12035-023-03881-z. doi: 10.1007/s12035-023-03881-z. Epub 2023 Dec 29 PMID: 38157119.

5.Nam C, Li LY, Yang Q, Ziman B, Zhao H, Hu B, Collet C, Jing P, Lei Q, Xu LY, Li EM, Koeffler HP, Sinha UK, Lin DC. A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2320835121. doi: 10.1073/pnas.2320835121. Epub 2024 Jun 20. PMID: 38900797.

6.Zheng YQ, Huang HH, Chen SX, Xu XE, Li ZM, Li YH, Chen SZ, Luo WX, Guo Y, Liu W, Li EM*, Xu LY*. Discovery and validation of combined biomarkers for the diagnosis of esophageal intraepithelial neoplasia and esophageal squamous cell carcinoma. J Proteomics. 2024 Jun 24:105233. doi: 10.1016/j.jprot.2024.105233. Epub ahead of print. PMID: 38925350.

7.Huang QF, Wang GF, Zhang YM, Zhang C, Ran YQ, He JZ, Wang G, Xu XE, Wang SH, Wu JY, Li EM*, Xu LY*. Lympho-myeloid aggregate-infiltrating CD20+B cells display a double-negative phenotype and correlate with poor prognosis in esophageal squamous cell carcinoma. Transl Res. 2024 Nov 11:S1931-5244(24)00186-5. doi: 10.1016/j.trsl.2024.11.002. Epub ahead of print. PMID: 39536938.

8.Li DJ, Cheng YW, Pan JM, Guo ZC, Wang SH, Huang QF, Nie PJ, Shi WQ, Xu XE, Wen B, Zhong JL, Zhang ZD, Wu ZY, Zhao H, Liao LD, Wu JY, Zhang K, Dong G, Li EM, Xu LY. KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. J Pathol. 2024 May;263(1):74-88. doi: 10.1002/path.6261. Epub 2024 Feb 27. PMID: 38411274.

9.Liu YQ, Xu YW, Zheng ZT, Li D, Hong CQ, Dai HQ, Wang JH, Chu LY, Liao LD, Zou HY, Li EM, Xie JJ, Fang WK. Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression. J Pathol. 2024 May;263(1):99-112. doi: 10.1002/path.6264. Epub 2024 Feb 27. PMID: 38411280.

10.Nam C, Li LY, Yang Q, Ziman B, Zhao H, Hu B, Collet C, Jing P, Lei Q, Xu LY, Li EM, Koeffler HP, Sinha UK, Lin DC. A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2320835121. doi: 10.1073/pnas.2320835121. Epub 2024 Jun 20. PMID: 38900797; PMCID: PMC11214090.

11.Hong P, Xu T, Xu J, Chen W, Hu H, Chen J, Li L, Zheng C, Li B, Liu J, Dai W, Li E, Zhang F, Xu W. CD24 promotes metastasis and chemoresistance by directly targeting Arf6-ERK pathway in esophageal squamous cell carcinoma. Cancer Lett. 2024 Jul 10;594:216994. doi: 10.1016/j.canlet.2024.216994. Epub 2024 May 25. PMID: 38801885.

12.Li ZM, Liu W, Chen XL, Wu WZ, Xu XE, Chu MY, Yu SX, Li EM, Huang HC, Xu LY. Construction and validation of classification models for predicting the response to concurrent chemo-radiotherapy of patients with esophageal squamous cell carcinoma based on multi-omics data. Clin Res Hepatol Gastroenterol. 2024 Apr;48(4):102318. doi: 10.1016/j.clinre.2024.102318. Epub 2024 Mar 11. PMID: 38471582.

13.Pan D, Long L, Li C, Zhou Y, Liu Q, Zhao Z, Zhao H, Lin W, Zheng Z, Peng L, Li E, Xu L. Splicing factor hnRNPA1 regulates alternative splicing of LOXL2 to enhance the production of LOXL2Δ13. J Biol Chem. 2024 Jul;300(7):107414. doi: 10.1016/j.jbc.2024.107414. Epub 2024 May 27. PMID: 38810697; PMCID: PMC11259713.

14.Gao W, Lu J, Yang Z, Li E, Cao Y, Xie L. Mitotic Functions and Characters of KIF11 in Cancers. Biomolecules. 2024 Mar 22;14(4):386. doi: 10.3390/biom14040386. PMID: 38672404; PMCID: PMC11047945.

15.Wu X, Li D, Chen Y, Wang L, Xu LY, Li EM, Dong G. Fascin - F-actin interaction studied by molecular dynamics simulation and protein network analysis. J Biomol Struct Dyn. 2024 Jan-Feb;42(1):435-444. doi: 10.1080/07391102.2023.2199083. Epub 2023 Apr 8. PMID: 37029713.

16.Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM. Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma. Cell Death Differ. 2023 Feb;30(2):527-543. doi: 10.1038/s41418-022-01104-x. Epub 2022 Dec 16. PMID: 36526897; PMCID: PMC9950447.

17.Dong H, Zhang J, Zhang H, Han Y, Lu C, Chen C, Tan X, Wang S, Bai X, Zhai G, Tian S, Zhang T, Cheng Z, Li E, Xu L, Zhang K. YiaC and CobB regulate lysine lactylation in Escherichia coli. Nat Commun. 2022 Nov 4;13(1):6628. doi: 10.1038/s41467-022-34399-y. PMID: 36333310; PMCID: PMC9636275.

18.Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY. Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer. Mol Cell Proteomics. 2023 Jun;22(6):100551. doi: 10.1016/j.mcpro.2023.100551. Epub 2023 Apr 17. PMID: 37076047; PMCID: PMC10205543.

19.Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L. Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2023 Nov 15;117(4):966-978. doi: 10.1016/j.ijrobp.2023.05.031. Epub 2023 May 26. PMID: 37244629.

20.Zhang Y, Zhang Y, Song C, Zhao X, Ai B, Wang Y, Zhou L, Zhu J, Feng C, Xu L, Wang Q, Sun H, Fang Q, Xu X, Li E, Li C. CRdb: a comprehensive resource for deciphering chromatin regulators in human. Nucleic Acids Res. 2023 Jan 6;51(D1):D88-D100. doi: 10.1093/nar/gkac960. PMID: 36318256; PMCID: PMC9825595.

21.Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM, Xu LY. Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin. Mol Cell Proteomics. 2023 Aug;22(8):100593. doi: 10.1016/j.mcpro.2023.100593. Epub 2023 Jun 15. PMID: 37328063; PMCID: PMC10393820.

22.He JZ, Chen Y, Zeng FM, Huang QF, Zhang HF, Wang SH, Yu SX, Pang XX, Liu Y, Xu XE, Wu JY, Shen WJ, Li ZY, Li EM, Xu LY. Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer. J Exp Clin Cancer Res. 2023 May 31;42(1):136. doi: 10.1186/s13046-023-02697-y. PMID: 37254126; PMCID: PMC10230698.

23.Kang L, Liu Y, He J, Wang Y, Xue M, Wu X, Wang Z, Zhang Y, Chu M, Li J, Wei W, Li J, Li E, Liao L, Xiao J, Zhang R, Xu L, Wong J. GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma. Oncogene. 2023 Jul;42(30):2297-2314. doi: 10.1038/s41388-023-02748-w. Epub 2023 Jun 22. PMID: 37349645.

24.Zheng SJ, Li EM, Xu LY. ASO Author Reflections: A Multiomic Novel Staging System for Esophageal Squamous Cell Carcinoma Patients. Ann Surg Oncol. 2023 Apr;30(4):2242-2243. doi: 10.1245/s10434-022-13041-7. Epub 2022 Dec 29. PMID: 36581725.

25.Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM. Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer. Biomedicines. 2023 Apr 16;11(4):1184. doi: 10.3390/biomedicines11041184. PMID: 37189802; PMCID: PMC10135950.

26.Zheng SJ, Zheng CP, Zhai TT, Xu XE, Zheng YQ, Li ZM, Li EM, Liu W, Xu LY. Development and Validation of a New Staging System for Esophageal Squamous Cell Carcinoma Patients Based on Combined Pathological TNM, Radiomics, and Proteomics. Ann Surg Oncol. 2023 Apr;30(4):2227-2241. doi: 10.1245/s10434-022-13026-6. Epub 2022 Dec 31. PMID: 36587172.

27.Wu X, Xu LY, Li EM, Dong G. Molecular dynamics simulation study on the structures of fascin mutants. J Mol Recognit. 2023 Jan;36(1):e2998. doi: 10.1002/jmr.2998. Epub 2022 Oct 28. PMID: 36225126.

28.Xie W, Peng Z, Zhou X, Xia Q, Chen M, Zheng X, Sun H, Zou H, Xu L, Du Z, Li E, Wu B. The Expression Pattern and Clinical Significance of Lysyl Oxidase Family in Gliomas. Dokl Biochem Biophys. 2023 Jun;510(1):132-143. doi: 10.1134/S1607672922600269. Epub 2023 Aug 15. PMID: 37582875.

29.Wang J, Chen C, Huang J, Xie Z, Chen X, Zheng Z, Li E, Zou H. The possibilities of LOXL4 as a prognostic marker for carcinomas. Amino Acids. 2023 Nov;55(11):1519-1529. doi: 10.1007/s00726-023-03343-9. Epub 2023 Oct 9. PMID: 37814029.

30.Xia Q, Du Z, Chen M, Zhou X, Bai W, Zheng X, Lin L, Zhao Y, Ding J, Wu Z, Zou H, Wang S, Xu L, Li E, Wu B. A protein complex of LCN2, LOXL2 and MMP9 facilitates tumour metastasis in oesophageal cancer. Mol Oncol. 2023 Nov;17(11):2451-2471. doi: 10.1002/1878-0261.13529. Epub 2023 Oct 4. PMID: 37753805; PMCID: PMC10620126.

31.Chu LY, Wu FC, Fang WK, Hong CQ, Huang LS, Zou HY, Peng YH, Chen H, Xie JJ, Xu YW. Secreted proteins encoded by super enhancer-driven genes could be promising biomarkers for early detection of esophageal squamous cell carcinoma. Biomed J. 2024 Aug;47(4):100662. doi: 10.1016/j.bj.2023.100662. Epub 2023 Sep 27. PMID: 37774793; PMCID: PMC11340493.

32.Wu Z, Huang Z, Zhou X, Gao C, Peng Z, Zheng X, Zhang Y, Du Z, Wu B. Comprehensive analysis of cuproptosis genes and cuproptosis-related genes as prognosis factors in esophageal squamous cell carcinoma. Genomics. 2023 Nov;115(6):110732. doi: 10.1016/j.ygeno.2023.110732. Epub 2023 Oct 20. PMID: 37866660.

33.Bei M, Hao S, Lin K, Chen Q, Cai Y, Zhao X, Jiang L, Lin L, Dong G, Xu J. Splicing factor TRA2A contributes to esophageal cancer progression via a noncanonical role in lncRNA m6 A methylation. Cancer Sci. 2023 Aug;114(8):3216-3229. doi: 10.1111/cas.15870. Epub 2023 Jun 14. PMID: 37317053; PMCID: PMC10394134.

34.Ng TK, Ji J, Liu Q, Yao Y, Wang WY, Cao Y, Chen CB, Lin JW, Dong G, Cen LP, Huang C, Zhang M. eva luation of Myocilin Variant Protein Structures Modeled by AlphaFold2. Biomolecules. 2023 Dec 21;14(1):14. doi: 10.3390/biom14010014. PMID: 38275755; PMCID: PMC10813463.

35.Cen LP, Ng TK, Ji J, Lin JW, Yao Y, Yang R, Dong G, Cao Y, Chen C, Yao SQ, Wang WY, Huang Z, Qiu K, Pang CP, Liu Q, Zhang M. Artificial Intelligence-based database for prediction of protein structure and their alterations in ocular diseases. Database (Oxford). 2023 Dec 18;2023:baad083. doi: 10.1093/database/baad083. PMID: 38109881; PMCID: PMC10727695.

36.Fu C, Xiang ML, Chen S, Dong G, Liu Z, Chen CB, Liang J, Cao Y, Zhang M, Liu Q. Molecular Drug Simulation and Experimental Validation of the CD36 Receptor Competitively Binding to Long-Chain Fatty Acids by 7-Ketocholesteryl-9-carboxynonanoate. ACS Omega. 2023 Jul 28;8(31):28277-28289. doi: 10.1021/acsomega.3c02082. PMID: 37576668; PMCID: PMC10413453.

37.Pan JM, Wang LD, Xu LY, Li EM, Dong G. Prediction of The Binding Mode of NP-G2-044 Targeting Fascin and Its Drug Resistance Mutations. Advanced Theory and Simulations, 2023;7:2300427.

38.Sun Z, Li Y, Tan X, Liu W, He X, Pan D, Li E, Xu L, Long L. Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer. Biomolecules. 2023 Mar 5;13(3):477. doi: 10.3390/biom13030477. PMID: 36979412; PMCID: PMC10046484.

39.Li C, Pan D, Lin W, Deng D, Zhou Y, Zhao H, Pan F, Xu L, Li E, Long L. RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells. Genes Dis. 2023 Jun 24;11(3):100990. doi: 10.1016/j.gendis.2023.04.024. PMID: 38274384; PMCID: PMC10808919.

40.Chien W, Tyner JW, Gery S, Zheng Y, Li LY, Gopinatha Pillai MS, Nam C, Bhowmick NA, Lin DC, Koeffler HP. Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR. J Ovarian Res. 2023 Apr 22;16(1):80. doi: 10.1186/s13048-023-01160-y. PMID: 37087441; PMCID: PMC10122390.

41.Chang L, Zhang XP, Liu WF *, Song XF, Sun SY, Fu DJ, Dong G, Wang ML, Bai YH, Liu XG. Thermo-responsive ion imprinted polymer on the surface of magnetic carbon nanospheres for recognizing and capturing low-concentration lithium ion. Minerals Engineering. 2023;201,108210.