部门简介 代表性论文：
1. Fang X, Huang W, Sun Q, Zhao Y, Sun R, Liu F, Huang D, Zhang Y, Gao F, Wang B. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life Sci. 2023 Nov 1;332:122108. doi: 10.1016/j.lfs.2023.122108.
2. Shafiq M, Bilal H, Permana B, Xu D, Cai G, Li X, Zeng M, Yuan Y, Jiao X, Yao F. Characterization of antibiotic resistance genes and mobile elements in extended-spectrum β-lactamase-producing Escherichia coli strains isolated from hospitalized patients in Guangdong, China. J Appl Microbiol. 2023 Jul 4;134(7):lxad125. doi: 10.1093/jambio/lxad125.
3. Chen W, Huang Y, Jiao X, Ye J, Lin Y, Yao F. Loss of erm(B)-Mediated rRNA Dimethylation and Restoration of Erythromycin Susceptibility in Erythromycin-Resistant Enterococci Following Induced Linezolid Resistance. Microb Drug Resist. 2023 Feb;29(2):51-58. doi: 10.1089/mdr.2022.0140.
4. Yu H, Li E, Liu S, Wu Z, Gao F. Identification of Signature Genes in the PD-1 Relative Gastric Cancer Using a Combined Analysis of Gene Expression and Methylation Data. J Oncol. 2022 Dec 15;2022:4994815. doi: 10.1155/2022/4994815.
5. Li H, Zheng F, Zhang Y, Sun J, Gao F, Shi G. Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level. J Cell Mol Med. 2022 Aug;26(15):4216-4229. doi: 10.1111/jcmm.17431.
6. Li H, Yang DH, Zhang Y, Zheng F, Gao F, Sun J, Shi G. Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury. Chin Med. 2022 Jun 17;17(1):73. doi: 10.1186/s13020-022-00616-5.
7. Huang X, Wang B, Shen H, Huang D, Shi G.Farnesoid X receptor functions in cervical cancer via the p14 (ARF)- mouse double minute 2-p53 pathway. Mol Biol Rep. 2022 May;49(5):3617-3625. doi: 10.1007/s11033-022-07201-x.
8. Tao W, Zhao C, Lin G, Wang Q, Lv Q, Wang S, Chen Y. UPLC-ESI-QTOF-MS/MS Analysis of the Phytochemical Compositions From Chaenomeles speciosa (Sweet) Nakai Fruits. J Chromatogr Sci. 2022 Dec 29;61(1):15-31. doi:10.1093/chromsci/bmac002.
9. Bao M, Huang W, Zhao Y, Fang X, Zhang Y, Gao F, Huang D, Wang B, Shi G. Verapamil Alleviates Myocardial Ischemia/Reperfusion Injury by Attenuating Oxidative Stress via Activation of SIRT1. Front Pharmacol. 2022 Feb 23;13:822640. doi: 10.3389/fphar.2022.822640.
10. Shen DF, Cheng H, Cai BZ, Cai WF, Wang B, Zhu Q, Wu YB, Liu M, Chen RJ, GaoFF, Zhang YM, Niu YD, Shi GG. N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice. Acta Pharmacol Sin. 2022 Jan;43(1):133-145. doi: 10.1038/s41401-021-00630-7.
11. Khan H, Ni Z, Feng H, Xing Y, Wu X, Huang D, Chen L, Niu Y, Shi G. Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling. Phytomedicine. 2021 Oct;91:153706. doi: 10.1016/j.phymed.2021.153706.
12. Wu J, Cai W, Du R, Li H, Wang B, Zhou Y, Shen D, Shen H, Lan Y, Chen L, Zheng X, Huang D, Shi G. Sevoflurane Alleviates Myocardial Ischemia Reperfusion Injury by Inhibiting P2X7-NLRP3 Mediated Pyroptosis. Front Mol Biosci. 2021 Oct 26;8:768594. doi: 10.3389/fmolb.2021.768594. Erratum in: Front Mol Biosci. 2022 Apr 13;9:901322.
13. Wang B, Li J, Bao M, Chen R, Li H, Lu B, Chen M, Huang D, Zhang Y, Gao F, Shi G. Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway. Oxid Med Cell Longev. 2021 May 27;2021:8882130. doi: 10.1155/2021/8882130. Erratum in: Oxid Med Cell Longev. 2021 Dec 11;2021:9793010.
14. Huang X, Wang B, Chen R, Zhong S, Gao F, Zhang Y, Niu Y, Li C, Shi G. The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical Cancer Cell Proliferation. Front Cell Dev Biol. 2021 Apr 6;9:583146. doi: 10.3389/fcell.2021.583146.
15. Ni Z, Lu J, Huang W, Khan H, Wu X, Huang D, Shi G, Niu Y, Huang H. Transcriptomic Identification of HBx-Associated Hub Genes in Hepatocellular Carcinoma. PeerJ. 2021 Dec 22;9:e12697. doi: 10.7717/peerj.12697.
16. Niu Y, Chen L, Wu M, Huang W, Wu X, Huang D, Xie Y, Shi G. Partial abrogationof FXR-KNG1 signaling by carboxyl-terminal truncated HBx-C30 in hepatitis Bvirus-associated hepatocellular carcinoma. Virus Res. 2021 Feb;293:198264. doi:10.1016/j.virusres.2020.198264.
17. Niu Y, Fan S, Luo Q, Chen L, Huang D, Chang W, Qin W, Shi G. Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis. J Clin Transl Hepatol. 2021 Aug 28;9(4):466-476. doi: 10.14218/JCTH.2021.00036.
18. Li H, Qi Z, Niu Y, Yang Y, Li M, Pang Y, Liu M, Cheng X, Xu M, Wang Z. FBP1 regulates proliferation, metastasis and chemoresistance by participating in C-MYC/STAT3 signaling axis in ovarian cancer. Oncogene. 2021 Oct;40(40):5938-5949. doi: 10.1038/s41388-021-01957-5.
19. He L, Jiang H, Lai Z, Zhong Z, Huang Z.Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma. BMC Cancer. 2021 Sep 6;21(1):992. doi: 10.1186/s12885-021-08736-1.
20. Zhao C, Wei M, Zheng Y, Tao W, Lv Q, Wang Q, Wang S, Chen Y. The Analyses of Chemical Components From Oldenlandia hedyotidea (DC.) Hand.-Mazz and Anticancer Effects in vitro. Front Pharmacol. 2021 May 10;12:624296. doi:10.3389/fphar.2021.624296.
21. Yuan Y, Chen Y, Yao F, Zeng M, Xie Q, Shafiq M, Noman SM, Jiao X. Microbiomes and Resistomes in Biopsy Tissue and Intestinal Lavage Fluid of Colorectal Cancer. Front Cell Dev Biol. 2021 Sep 17;9:736994. doi: 10.3389/fcell.2021.736994.
22. Zhang S, Zheng F, Zhang L, Huang Z, Huang X, Pan Z, Chen S, Xu C, Jiang Y, Gu S, Zhao C, Zhang Q, Shi G*. LncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells. J Exp Clin Cancer Res. 2020 Jul 11;39(1):131. doi: 10.1186/s13046-020-01610-1.
23. Zaifa Hong , Mingen Lin , Yanmei Zhang , Zhimin He , Liling Zheng , Shuping Zhong . Role of Betaine in Inhibiting the Induction of RNA Pol III Gene Transcription and Cell Growth Caused by Alcohol. Chem Biol Interact. 2020 Jul 1;325:109129. doi: 10.1016/j.cbi.2020.109129.
24. Songlin Chen , Yunfeng Yi , Ting Xia , Zaifa Hong , Yanmei Zhang , Ganggang Shi , Zhimin He , Shuping Zhong. The influences of red wine in phenotypes of human cancer cells. Gene. 2019 Jun 20;702:194-204. doi: 10.1016/j.gene.2018.10.049.
25. Xiaorui Cai , Shulin Zhao , De Cai , Jinhong Zheng , Zhiwei Zhu , Duncan Wei , Zhiwei Zheng , Huide Zhu , Yicun Chen. Synthesis and eva luation of novel D-ring substituted steroidal pyrazolines as potential anti-inflammatory agents. Steroids. 2019 Jun;146:70-78. doi: 10.1016/j.steroids.2019.03.012.
26. Fenfei Gao , Dejie Chen , Xiaokuang Ma , Sterling Sudweeks , Jordan T Yorgason , Ming Gao , Dharshaun Turner , Jason Brek Eaton , J Michael McIntosh , Ronald J Lukas , Paul Whiteaker , Yongchang Chang, Scott C Steffensen, Jie Wu. Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol. Neuropharmacology. 2019 May 1;149:45-54. doi: 10.1016/j.neuropharm.2019.01.021.
27. Dejie Chen, Fenfei Gao , Xiaokuang Ma , Jason Brek Eaton, Yuanbing Huang , Ming Gao , Yongchang Chang, Zegang Ma , Taleen Der-Ghazarian , Janet Neisewander , Paul Whiteaker , Jie Wu, Quanxi Su .Cocaine Directly Inhibits alpha6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons. Front Pharmacol. 2019 Feb 14;10:72. doi: 10.3389/fphar.2019.00072.
28. Xiaobing Hong , Zelin Yu , Zhonglin Chen , Hongyan Jiang , Yongdong Niu , Zhanqin Huang High molecular weight fibroblast growth factor 2 induces apoptosis by interacting with complement component 1 Q subcomponent–binding protein in vitro. J Cell Biochem. 2018 Nov;119(11):8807-8817. doi: 10.1002/jcb.27131.
29. Chu Q, Zhang Y, Zhong S, Gao F, Chen Y, Wang B, Zhang Z, Cai W, Li W, Zheng F*,Shi G*. N-n-Butyl Haloperidol Iodide Ameliorates Oxidative Stress in Mitochondria Induced by Hypoxia/Reoxygenation through the Mitochondrial c-Jun N-Terminal Kinase/Sab/Src/Reactive Oxygen Species Pathway in H9c2 Cells. Oxid Med Cell Longev. 2019 May 8;2019:7417561. doi: 10.1155/2019/7417561. eCollection 2019.
30. Cai W, Zhong S, Zheng F, Zhang Y, Gao F, Xu H, Cai X, Lan J, Huang D, Shi G*.Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway. IUBMB Life. 2018 Nov 19. doi: 10.1002/iub.1967.
31. Li W, Shi G*. How Ca(V)1.2-bound verapamil blocks Ca(2+) influx into cardiomyocyte: Atomic level views. Pharmacol Res. 2018 Nov 14;139:153-157.
32. Zhongjie Huang, a Yicun Chen, b Daojun Liu,* c Chao Lu, c Zhiwei Shen, d Shuping Zhong e and Ganggang Shi * b.Gadolinium-conjugated star-block copolymer polylysine-modified polyethylenimine as high-performance T1 MR imaging blood pool contrast agents.RSC Advances.
33. Zhankui Yan, Daifei Shen , Jilin Liao, Yanmei Zhang , Yicun Chen , Ganggang Shi , Fenfei Gao. Hypoxia Suppresses TGF-B1-Induced Cardiac Myocyte Myofibroblast Transformation by Inhibiting Smad2/3 and Rhoa Signaling Pathways. Cell Physiol Biochem. 2018;45(1):250-257. doi: 10.1159/000486771.
34. Hui Luo 1, Kristofer Wood 2, Fu-Dong Shi 2, Fenfei Gao 3, Yongchang Chang .Suramin is a novel competitive antagonist selective to alpha1beta2gamma2 GABAA over rho1 GABAC receptors.Neuropharmacology.2018Oct;141:148-157.doi:10.1016/j.neuropharm.2018.08.036.
35. De-Jie Chen, Fen-Fei Gao, Xiao-Kuang Ma, Gang-Gang Shi, Yuan-Bing Huang, Quang-Xi Su, Sterling Sudweeks, Ming Gao, Turner Dharshaun, Jason Brek Eaton, Yong-Chang Chang, J Michael Mcintosh, Ronald J Lukas, Paul Whiteaker, Scott C Steffensen, Jie Wu.Pharmacological and functional comparisons of alpha6/alpha3beta2beta3-nAChRs and alpha4beta2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line. Acta Pharmacol Sin. 2018 Oct;39(10):1571-1581. doi: 10.1038/aps.2017.209.
36. Sun T, Zhang Y, Zhong S, Gao F, Chen Y, Wang B, Cai W, Zhang Z, Li W, Lu S, Zheng F, Shi G. N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells. Front Pharmacol. 2018 Jan 25;9:19.
37. Guo-Wu Liang , Yi-Cun Chen , Yi Wang , Hong-Mei Wang , Xiang-Yu Pan , Pei-Hong Chen , Qing-Xia Niu.Interaction between Saikosaponin D, Paeoniflorin,and Human Serum Albumin. Molecules. 2018 Jan 27;23(2):249. doi: 10.3390/molecules23020249.
38. Yan Z, Shen D, Liao J, Zhang Y, Chen Y, Shi G, Gao F. Hypoxia Suppresses TGF-B1-Induced Cardiac Myocyte Myofibroblast Transformation by Inhibiting Smad2/3 and Rhoa Signaling Pathways. Cell Physiol Biochem.2018;45(1):250-257.
专利及其他成果：
1. 国家发明专利：牛白藤总环烯醚萜提取物、提取纯化方法及其应用。陈一村，李春泉，林泳冰，郑伊琳。专利号：ZL 2021 1 0116605.7
2. 国家发明专利：一种人参与石斛中药合剂及其应用。陈一村，詹华强，董婷霞，陈沛洪，李春泉。专利号：ZL 2020 11236764.2
3. 国家发明专利：一种朱槿花苞提取物及其应用。石刚刚，姜霁洋。专利号：ZL 2014 1 0665498.3
4. 国家发明专利：一种鹿角海萝多糖。石刚刚，陈一村，江泽斌，郑娇娇。 专利号：ZL 2015 1 0255589.4
5. 国家国家发明专利：具有心血管活性的氟哌啶醇季铵盐衍生物。石刚刚，郑锦鸿，陈少刚。专利号：ZL 96 1 19098.1
6. 国家实用新型专利：一种握笔式移液枪。张浴玲，高分飞，黄玮仪，黄丹梅。ZL 2021 2 2227290.1
7. 国家实用新型专利：一种静配中心专用的药框清洗装置。方翎，张浴玲，高分飞。专利号：ZL 2021 22102668.5
8. 国家实用新型专利：一种温控培养皿细胞浴槽。高分飞。专利号：ZL 2019 2 0363396.4
9. 国家实用新型专利：一种二合一离体灌流心脏希氏束电图记录电极。高分飞。专利号：ZL 2011 2 0571610.9
10. 国家实用新型专利：改良的脑片/组织片的孵育盒。高分飞。专利号：ZL201620446921.5
11. 朱槿花广东省中药材标准制定及其应用：2019年入选广东省中药材标准，目前正在与制药企业联合申报广东省产学研项目，并且与汕头市皮肤病医院开展合作，将朱槿花苞提取物制作成新型膏剂，观察其对于难治性皮肤溃疡的治疗效果。
