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药剂学教研室
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研究成果

1. D.G. Yang; C. Liu; P. Quan; L. Fang∗; A systematic approach to determination of permeation enhancer action efficacy and sites: Molecular mechanism investigated by quantitative structure−activity relationship, J. Control. Release, 2020, 322: 1-12.

2. D.G. Yang, C. Liu, P. Quan, L. Fang∗, Molecular mechanism of high capacity-high release transdermal drug delivery patch with carboxyl acrylate polymer: Roles of ion-ion repulsion and hydrogen bond, Int. J. Pharm. 2020, 585:119376.

3. D.G. Yang, C. Liu, D. Ding, P. Quan, L. Fang∗, The molecular design of drug-ionic liquids for transdermal drug delivery: Mechanistic study of counterions structure on complex formation and skin permeation, Int. J. Pharm. 2021, 602:120560.

4. D.G. Yang, C. Liu, H.Q. Piao, P. Quan, L. Fang∗, Enhanced drug loading in the drug-in-adhesive transdermal patch utilizing a drug-ionic liquid strategy: Insight into the role of ionic hydrogen bonding, Mol. Pharm. 2021, 18:1157–66.

5. D.G. Yang, L. Fang, C.R. Yang∗, Roles of molecular interaction and mobility on loading capacity and release rate of drug-ionic liquid in long-acting controlled release transdermal patch, J. Mol. Liq. 2022, 352:118752.

6. D.G. Yang, X.J. Chen, Z.Q. Li, C.R. Yang∗, Mechanistic study of release characteristics of two active ingredients in transdermal patch containing lidocaine−flurbiprofen ionic liquid, Pharmaceutics 2022,14:2158.

7. D.G. Yang, Y.H. Zhang, Z.Q. Li, X.J. M.Y. Liu, C.R. Yang∗, Design of dual-targeted pH-sensitive hybrid polymer micelles for breast cancer treatment: Three birds with one stone, Pharmaceutics 2023,15:1580.

8. JY. Zhang, B. Gu, S.M. Wu, Y. Gao, D.G. Yang∗, J. Du∗, C.R. Yang∗, M1 macrophage-biomimetic targeted nanoparticles containing oxygen self-supplied enzyme for enhancing the chemotherapy, Pharmaceutics 2023,15:2243.

9. X.J. Chen, Z.Q. Li, C.R. Yang∗, D.G. Yang∗, Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges, Asian J. Pharm. Sci. 2024,19: 100900.

10. L. Liu, Y.C. Yao, Y. Liu, B.R. Hong, Z.Q. Li, X.J. Chen, Y.F. Zhang, H.B. Fu, D.G. Yang∗, C.R. Yang∗, Targeted H2S-mediated gas therapy with pH-sensitive release property for myocardial ischemia–reperfusion injury by platelet membrane, Biomater. Res. 2024, 28:0061.

11. X.J. Chen, L. Liu, B.R. Hong, Y. Liu, Z.Q. Li, X.Y. Liu, C.R. Yang∗, D.G. Yang∗, The molecular design of novel phospholipid-inspired ionic liquid transdermal penetration enhancers: Innovative insights on the action mode and mechanism, Int. J. Pharm. 2024, 666: 124805.

12. Kai Ling; Jianlan Bu; Weijie Huang; Wenyue Kang; Qingpeng Yuan; Bingchun Zeng; Chuanghong Liao; Qiunuan Zheng; Guangrong Zhang; Xuanjun Zheng; Zeyang Chen; Xiaohong Jiang; Rui Li; Tiantian Zhai; Hongyan Jiang H ; Robust Cu2+-Modified Black Phosphorus Nanoplatform for Enhanced Drug Delivery and Synergistic Multimodal Tumor Therapy via Metal Ion-Assisted π-π Interactions, ACS Applied Materials & Interfaces, 2025, 10.1021/acsami.4c22168(IF=8.8,通讯作者)

13. Kai Ling, Jintao Zheng, Xiaohong Jiang, Weijie Huang, Youqing Mai, Chuanghong Liao, Shuting Fan, Jianlan Bu, Rui Li, Bingchun Zeng, Qiunuan Zheng, Ruibin Huang, Zhiyang Li, Nai-Kei Wong, Hongyan Jiang. Mn2+/CpG Oligodeoxynucleotides Codecorated Black Phosphorus Nanosheet Platform for Enhanced Antitumor Potency in Multimodal Therapy[J]. ACS nano, 2024, 18(4): 2841-2860.(IF=17.1, 通讯作者)

14. Hongyan Jiang, Qing Xia, Jintao Zheng, Jianlan Bu, Rui Li, Zehong Cai, Kai Ling. Mn2+ modified black phosphorus nanosheets with enhanced DNA adsorption and affinity for robust sensing[J]. Biosensors and Bioelectronic, 2022, 216: 114622.(IF=12.6, 第一作者)

15. Qing Xia, Jingtao Zheng, Jianlan Bu, Rui Li, Xinxin Li, Shuting Fan, Kai Ling, Hongyan Jiang. Mn2+modifed black phosphorus nanosensor for detection of exosomal microRNAs and exosomes[J]. Microchimica Acta, 2023, 190.(IF=5.7, 共同通讯)

16. Calcium-cation-doped polydopamine-modified 2D black phosphorus nanosheets as a robust platform for sensitive and specific biomolecule sensing[J]. Analytica Chimica Acta, 2020,1121:1-10. (IF=6.228, 第一作者)

17. Hongyan Jiang, Fu-Rong Li, Wei Li, Xiaodong Lu, Kai Ling. Multiplexed determination of intracellular messenger RNA by using a grapheme oxide nanoprobe modified with target-recognizing fluorescent oligonucleotides[J]. Mikrochim Acta, 2018, 185(12): 552. (IF=5.705, 第一作者)  

18. Kai Ling, Hongyan Jiang, Xue Huang, Yang Li, Juanjuan Lin, Fu-Rong Li. Direct chemiluminescence detection of circulating microRNAs in serum samples using a single-strand specific nuclease-distinguishing nucleic acid hybrid system[J]. Chemical Communications, 2018, 54(15): 1909-1912. (IF=6.29, 共同第一作者)  

19. Kai Ling, Hongyan Jiang, Linlin Zhang, Yang Li, Lu Yang, Chen Qiu, Fu-Rong Li. A self-assembling RNA aptamer-based nanoparticle sensor for fluorometric detection of Neomycin B in milk[J]. Analytical and Bioanalytical Chemistry , 2016, 408, 3593-3600. (IF=4.3, 共同第一作者)                                                                                                     

20. Kai Ling, Hongyan Jiang, Yang Li, Xiaojun Tao, Chen Qiu, and Fu-Rong Li. A self-assembling RNA aptamer based graphene oxide sensor for the turn-on detection of theophylline in serum [J]. Biosensors and Bioelectronics, 2016, 86, 8-13. (IF=12.6, 共同第一作者).

21. Hongyan Jiang, Kai Ling, Xiaojun Tao, and Qiqing Zhang. Theophylline detection in serum using a self-assembling RNA aptamer-based gold nanoparticle sensor[J]. Biosensors and Bioelectronics, 2015, 70, 299-303. (IF=12.6, 第一作者)  

22. Ling, K, Jiang, H, Zhang, Q. A colorimetric method for the molecular weight determination of polyethylene glycol using gold nanoparticles[J]. Nanoscale Research letters, 2013, 8, 538. (IF=6.5, 第二作者)


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